https://www.reviewofophthalmology.com/article/retinal-angiomatous-proliferation-in-amd
RAP can be treated early with laser coagulation. Later on it makes VGEF inhibitors much less effective. It's present in about 10% of the AMD population. But if it was a similar proportion in both the control and treatment arms it wouldn't be expected to change the study outcome. But it might not have a similar incidence so screening it out should give a more accurate result.
Hang in there!!, page-138
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