HF-MACE and P3 ( dyor )

Fellow HC posters,

With all the banter that occurred over the last week or so re the P2 results – I reached out to a specialist and provided the various material ( i.e. Research Papers ; Critiques; HC posts ect.).

This was the commentary and my understanding (in my words):

Uneducated people can always be led astray by those wanting to continue to perpetuate falsehoods.
When these falsehoods are given the aura of science, but are really pseudoscience, they are particularly misleading to the average investor.

The internet and especially this chatroom thread is full of pseudoscience.

Let’s go through the results one more time…

• Mesoblast has repeatedly shown in its public documents, and was shown in the  Emerson Perin paper in Circulation Research, there was a dose dependent reduction in both systolic and diastolic volumes at 6 and 12 months, with the reduction achieved by the highest dose being statistically significant against placebo.
• These volume changes are called surrogates and are well validated to predict subsequent reduction in heart failure hospitalizations and death (HF-MACE), which the high dose achieved over three years.
• The two are linked mechanistically.
• Whether the observed reduction in HF-MACE was post-hoc or not, it was a real fact  -   not one patient injected with the high dose had ANY hospitalizations or deaths over three years.

If  Hot Tuna thinks any injection into the myocardium  can miraculously result in reduced HF-MACE events (as he says) then there are many previous studies injecting all sorts of materials into damaged hearts that did not improve HF-MACE.

Do your research and don’t listen to those shorters who are trying to bring every one down to their level.

(The above is my researched opinion , following discussion with a specialist )

Good Luck to all holders.
Anjo.


(ps : more research coming soon ).