Histological Comparison of Kidney Tissue Following Radioembolization with Yttrium-90

http://link.springer.com/article/10.1007/s00270-016-1482-3

Full version as per the link, below is the abstract.
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Histological Comparison of Kidney Tissue Following Radioembolization with Yttrium-90 Resin Microspheres and Embolization with Bland Microspheres

• Authors
• Authors and affiliations

• Suresh de SilvaEmail author
• Simon Mackie
• Peter Aslan
• David Cade
• Warick Delprado

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Laboratory Investigation
First Online:
14 October 2016

DOI: 10.1007/s00270-016-1482-3
Cite this article as:
de Silva, S., Mackie, S., Aslan, P. et al. Cardiovasc Intervent Radiol (2016). doi:10.1007/s00270-016-1482-3
Abstract

Background

Intra-arterial brachytherapy with yttrium-90 (⁹⁰Y) resin microspheres (radioembolization) is a procedure to selectively deliver high-dose radiation to tumors. The purpose of this research was to compare the radioembolic effect of ⁹⁰Y-radioembolization versus the embolic effect of bland microspheres in the porcine kidney model.
Methods

In each of six pigs, ~25–33 % of the kidney volume was embolized with ⁹⁰Y resin microspheres and an equivalent number of bland microspheres in the contralateral kidney. Kidney volume was estimated visually from contrast-enhanced fluoroscopy imaging. Morphologic and histologic analysis was performed 8–9 weeks after the procedure to assess the locations of the microspheres and extent of tissue necrosis from ⁹⁰Y-radioembolization and bland embolization. A semi-quantified evaluation of the non-acute peri-particle and perivascular tissue reaction was conducted. All guidelines for the care and use of animals were followed.
Results

Kidneys embolized with ⁹⁰Y-radioembolization decreased in mass by 30–70 % versus the contralateral kidney embolized with bland microspheres. These kidneys showed significant necrosis/fibrosis, avascularization, and glomerular atrophy in the immediate vicinity of the ⁹⁰Y resin microspheres. By contrast, glomerular changes were not observed, even with clusters of bland microspheres in afferent arterioles. Evidence of a foreign body reaction was recorded in some kidneys with bland microspheres, and subcapsular scarring/infarction only with the highest load (4.96 × 10⁶) of bland microspheres.
Conclusion

This study showed that radioembolization with ⁹⁰Y resin microspheres produces localized necrosis/fibrosis and loss of kidney mass in a porcine kidney model. This result supports the study of ⁹⁰Y resin microspheres for the localized treatment of kidney tumors.