Whatdo theseresultsmean forBIT225andBiotron’sHIV‐1Program?
‐ TheimmunologicaldataprovideclearclinicalevidencethatBIT225ishavingauniqueeffectinindividualsinfectedwithHIV‐1
‐ Thiseffectisnotseeninindividualstreatedwithcurre ntapprovedanti‐HIV ‐1drugs
‐ Thedataareconsiste ntwithBIT225’stargetingandclearanceof virusfrommacrophage cellreservoirs
‐ Theremaybeadditional benefits;analysesareon goingNew blood Assay test
‐ TheresultssupporttwopotentialfutureavenuesfordevelopmentofBIT225:
1.AsakeycomponentoffutureHIV‐1eradication/curestrategies
Acombination,ormulti‐drugapproach,willbe neededforsuccessfuleradi cationofHIV‐1infection
2.Asanadditiontocurrentanti‐HIVdrugstoreduceimmuneactivationmarkersandimprovepatienthealthoutcomes
‐ Addtoanal readyextensive bodyofpreclinicaland clinicaldataon BIT225generated overthelastde cade
‐ Potentiallyimprovethesaleabilityoftheprogramtoacommercialpartner,byprovidingevidenceofaclinicalbenefitoverandaboveART
HIV Wonder Drug BIT225, page-76
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