Vamorolone is a synthetic steroid, which is under development for the treatment of duchenne muscular dystrophy.
Anti-inflammatory drugs of the corticosteroid class show a carbonyl or hydroxyl group on the C11 carbon of the steroid backbone.The lack of deleterious changes in bone turnover markers in patients with DMD treated with vamorolone suggests a possible loss of bone morbidities typically associated with glucocorticoidsGlucocorticoid treatment is the most common cause of osteoporosis; fractures occur in 30% to 50% of patients with DMD receiving long-term therapy.27
A recent retrospective study of an inception cohort of 403,337 patients newly diagnosed with rheumatoid arthritis, asthma/chronic obstructive pulmonary disease, inflammatory bowel disease, multiple sclerosis, lupus, and sarcoidosis found 72% to be prescribed glucocorticoids (52% at age <50 years).28 Use of glucocorticoids was strongly associated with increased rate of fractures,
A novel dissociative steroidal anti-inflammatory drug, vamorolone, showed evidence of efficacy and reduction of safety concerns typically seen with traditional glucocorticoids in a 48-patient, open-label, exploratory, multiple-ascending-dose study in young patients with DMD.
———————————-
So comparing it to ATL1102..Vamorolone a dissociative steroid still has a great deal of side effects although not as much as corticosteroids... (bone fractures)
Vamorolone is for young DMD patients (4-7 yrs old )
Atl1102 has No side effects...
Hope that helps Mispec..
- Forums
- ASX - By Stock
- PER
- How does ATL1102 compare with Vamorolone
How does ATL1102 compare with Vamorolone, page-2
-
- There are more pages in this discussion • 27 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Featured News
Add PER (ASX) to my watchlist
(20min delay)
|
|||||
Last
10.5¢ |
Change
0.005(5.00%) |
Mkt cap ! $94.66M |
Open | High | Low | Value | Volume |
10.5¢ | 10.5¢ | 10.0¢ | $52.92K | 505.9K |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
4 | 103781 | 10.5¢ |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
11.0¢ | 394063 | 7 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
5 | 178781 | 0.105 |
11 | 744824 | 0.100 |
5 | 283191 | 0.099 |
3 | 408491 | 0.098 |
3 | 131927 | 0.097 |
Price($) | Vol. | No. |
---|---|---|
0.110 | 394063 | 7 |
0.115 | 763850 | 6 |
0.120 | 354642 | 9 |
0.125 | 110429 | 2 |
0.130 | 10000 | 1 |
Last trade - 14.33pm 10/10/2024 (20 minute delay) ? |
Featured News
PER (ASX) Chart |
The Watchlist
EL8
ELEVATE URANIUM LTD
Murray Hill, MD & CEO
Murray Hill
MD & CEO
Previous Video
Next Video
SPONSORED BY The Market Online