Thanks Bedger, much appreciated.

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28/06/21

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Post #: 54125237
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Originally posted by bedger: ↑

Bear in mind OCC are not just repairing simple severed nerves (the easier repair), many of the repairs they were doing were grafts of nerves that would not otherwise work, because of damage to the spinal column. They are grafting perpipheral nerves to provide motor function to Paraplegics that would not otherwise be there.

"....autografts sacrifice a functioning nerve (sensory), for a more important injured nerve (usually motor). There is sensory loss and scarring at the donor site and potential for neuroma formation. At the repair site there is unavoidable size and fascicle mismatch, scarring and fibrosis from sutures, tissue handling, and the injury itself and all of these factors lead to poor regeneration. A clinical rule of thumb is that there is a 50% loss of axons at each coaptation site. Therefore, for primary nerve repair, approximately 50% of the original axons will successfully regenerate through the repair site. For a nerve graft with two coaptation sites, 25% of axons will successfully regenerate through the graft. Depending on the distance to the motor/sensory target, there will then be additional axonal loss due to the effects previously discussed of chronic axotomy and muscle fibrosis".

https://www.hindawi.com/journals/bmri/2014/698256/

Remember as well OCC is describing eventual muscle function in their results. Whilst feeling maybe restored in many sutured autografts, that does not mean sufficient motor function will be restored as well. Love to get other data from other people, but from what I have studied the results are very convincing at 76.5%.

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Thanks Bedger, much appreciated.

OCC Price at posting: 59.5¢ Sentiment: Buy Disclosure: Held
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Thanks Bedger, much appreciated.

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Thanks Bedger, much appreciated.

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