How long before this seemingly effective anti-Covid drug is banned?

  1. hersuit
    15,760 Posts.
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    07/08/21
    18:38
    Post #: 55111307
    https://www.foxnews.com/health/cholesterol-drug-coronavirus-infection

    Pray Trump doesnt endorse it in any way lest some poor souls might be saved

    Cant have that.

    The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models

    1,2,3,www.frontiersin.orgHarriet J. Hill1,www.frontiersin.orgYen-Hsi Chen4,www.frontiersin.orgRichard Karlsson4,www.frontiersin.orgIeva Bagdonaite4,www.frontiersin.orgScott E. Guimond2,1,2,4,5,www.frontiersin.orgZhang Yang4,3,2,www.frontiersin.orgFarhat L. Khanim6*†and7*†
    1Institute for Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom2Molecular and Structural Bioscience, School of Life Sciences, Keele University, Staffordshire, United Kingdom3Viral Pathogenesis and Biosafety Unit, San Raffaele Scientific Institute Via Olgettina, Milano, Italy4Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark5Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom6School of Biomedical Sciences, Institute for Clinical Sciences, University of Birmingham, Birmingham, United Kingdom7School of Pharmacy and Bioengineering, Keele University, Staffordshire, United Kingdom

    The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to treat SARS-CoV-2 infections, we established a screen to measure the dimerization of angiotensin-converting enzyme 2 (ACE2), the primary receptor for the virus. This screen identified fenofibric acid, the active metabolite of fenofibrate. Fenofibric acid also destabilized the receptor-binding domain (RBD) of the viral spike protein and inhibited RBD binding to ACE2 in enzyme-linked immunosorbent assay (ELISA) and whole cell-binding assays. Fenofibrate and fenofibric acid were tested by two independent laboratories measuring infection of cultured Vero cells using two different SARS-CoV-2 isolates. In both settings at drug concentrations, which are clinically achievable, fenofibrate and fenofibric acid reduced viral infection by up to 70%. Together with its extensive history of clinical use and its relatively good safety profile, this study identifies fenofibrate as a potential therapeutic agent requiring an urgent clinical evaluation to treat SARS-CoV-2 infection.


    Last edited by hersuit: 07/08/21
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