Single case report, but very good especially for the pt! My...

Single case report, but very good especially for the pt!

My understanding is that there will never be a large Phase III trial for ICC, so these sorts of case studies are important to build the picture.

http://www.jgld.ro/wp/y2016/n3/a23.pdf

Multimodal Therapy including Yttrium-90 Radioembolization as a Bridging Therapy to Liver Transplantation for a Huge and Locally Advanced Intrahepatic Cholangiocarcinoma

Imaging (CT scan and MRI) revealed a huge liver tumor 12 cm in diameter arising from the right liver involving the three hepatic veins and the portal vein bifurcation. The intrahepatic bile ducts were moderately dilated due to external compression of the biliary confluence by the lesion. The tumor presented at least three tumoral satellite nodules in segments 2, 4 and 7 (Fig. 1). No extrahepatic spread was found on radiological investigations as well as on FDG-PET.
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Four months after radioembolization, imaging showed significant tumoral shrinkage (Fig. 1-C), but the lesion was still considered as unresectable owing to vascular involvement and persistent tumoral satellite nodules.
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Two years after LT, the patient presented with biliary anastomotic stricture requiring surgical repair. At the time of laparotomy, complete exploration of the abdominal cavity showed no signs of recurrence. Three years after LT, the patient is doing perfectly well. Liver function and CA19.9 blood level have remained within normal range and no sign of recurrence was found on imaging.