Human Application, page-10

Oh Crikey. I no longer hold, although current prices are a rather more attractive entry. I will have to say DYOR. Google "pubmed bromelain".
I used to use this stuff for its anti-inflammatory effects - good for the circulation. I've got 13 pages of stuff at hand on this. Here's SOME. Put your OWN fingers to work!
Bromelain (Pineapple enzyme)

GENERAL DESCRIPTION:
Bromelain is a proteolytic enzyme (an enzyme that digests proteins) found in fresh pineapple. It is often used to treat muscle injuries and as a digestive aid.

ROLE IN ANTI-AGING:
Bromelain is a natural anticoagulant that works by breaking down the blood-clotting protein fibrin. This may help to explain why results of at least two clinical trials suggest that the enzyme can help to improve the symptoms of angina and thrombophlebitis. As well as thinning the blood, bromelain also thins mucus, and thus maybe of benefit to asthmatics and people suffering from chronic bronchitis. There is also evidence that bromelain can trigger beneficial changes in white blood cells, and thus may improve immune function. However, whether or not the enzyme would be beneficial to immunocompromised people has not been established clinically. Bromelain has potent anti-inflammatory properties and therefore may be useful in promoting the healing of minor muscle injuries such as sprains and strains. Results of one study also found evidence to suggest that it can help to improve the symptoms of rheumatoid arthritis. When applied topically it may help to speed wound healing. There has also been some suggestion that bromelain has anti-cancer properties, although this has not been proven. Several recent studies have linked chronic inflammation to cancer, thus any anti-cancer action of bromelain could be due to it anti-inflammatory properties. The enzyme may also enhance the effect of the antibiotics amoxicillin, erythromycin, penicillamine, and penicillin. In a study of people with urinary tract infections,100% of participants given antibiotics in combination with bromelain and another enzyme called trypsin were cured of their infection, compared with just 46% who received antibiotics alone.
Bromelain aids digestion by enhancing the effects of the digestive enzymes trypsin and pepin. It can also help to prevent heartburn by ease diarrhea, if either are caused by a deficiency of digestive enzymes. Bromelain supplements often contain a plant pigment called quercetin. The two substances are found in combination simply because they enhance each other’s antiinflammatory actions, and that bromelain appears to improve quercetin absorption.

Bromelain supports healthy cardiovascular function.*

Evidence suggests that bromelain can modulate adhesion molecules on blood cells and the cells lining the walls of blood vessels, thereby promoting healthy circulation. Bromelain does so through its proteolytic activity—cleaving proteins from the surface of cells. Several important human proteins affected include fibrin, albumin, casein, angiotensin II and bradykinin. Fibrin and albumin are blood proteins that each provide contributions to the maintenance of a healthy blood flow, while angiotensin II and bradykinin play a role in the pliability of blood vessels. All of these compounds are highly involved in complex systems that are implicated in a healthy flow of blood and optimal cardiovascular health.1,11

While bromelain is most noted for its enzyme activity, not all of the physiological activity of bromelain can be attributed to its protease activity. It appears that the other compounds within bromelain act synergistically to provide its wealth of benefits.12 Given its wide range of activity, bromelain can be valued as a factor in healthy maintenance of multiple systems within the human body.

Pineapples

1. Improves your immunity
   Eating pineapples can improve your immunity as they are highly rich in Vitamin C. A strong immune system will keep most diseases and infections at bay, ensuring that you don’t fall ill.
   .
2. Strengthens your bones
   Pineapples are extremely great for your bones as they contain manganese, an ingredient that is vital for the healthy development of your bones.

1. Good for diabetics
   Diabetics who are frustrated about not being able to indulge in sweets can find some comfort in eating small amounts of pineapple. It has a medium GI meaning that it does not cause a spike in your blood sugar levels quickly. That said, make sure you don’t eat too much of the fruit and indulge in healthier alternatives like peas and lentils.

1. Prevents acidity
   Pineapple is a source of a digestive enzyme called bromelain which helps neutralize the acids in your stomach thus preventing acidity. It also contains some amount of fibre which helps clear the food stuck in your colon.

1. Gives you glowing skin
   The antioxidants present in pineapple help prevent signs of ageing like wrinkles and fine lines. Additionally, it has Vitamin C which helps in the production of collagen, a protein that helps grow new skin.

Pineapple provides your body with a lot of nutrients. Here are some of the best health benefits of eating pineapple -

1. Prevents Free Radical Damage
2. Thwarts Off Cold
3. Strong Bones
4. Healthy Gums
5. Macular Degeneration
6. Anti-inflammatory Action
7. Cures Sinusitis, Sore Throat, Gout, Swellings
8. Anti-cancer Properties
9. Atherosclerosis
10. Heart Health
11. Immunity
12. Digestion
13. Bronchitis
14. Catarrh

Finally, if you do decide to use it therapeutically, don't just by any supplement labeled bromelain as the potency is what counts, (which you will know if you DYOR). Doctors Best from the US is about as good as it gets.