Don't forget the influence of time on statistical significance too. You would hope the difference between the placebo and treatment groups would increase with time, whether that be from treatment groups remaining stable and placebo deteriorating further. Or more exiting would be the treatment groups improving and the placebo deteriorating further. So 12 months as opposed to 6 months for HD may be also a positive influence in increasing the difference between the groups.
The extension trial is going to be really fascinating. What if there is a marked difference between treatment arms in IMAGINE and then you get to follow up the placebo arm and see what happened to them when they actually went on the drug! The extension trial is open label, so correct me if I am wrong, but that would enable the company to report on 3 months, 6 months, 12 month follow ups, whatever they decided would be useful?
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