in-vivo non-viral delivery of shrna for mi, page-12

Sorry, I'm probably boring you all to tears with so much posting, but buying this minicircle technology just might be the best decision BLT ever made.

This is a news article on minicircles that makes it easier to understand and isn't as gruelling as reading a research report. Looks like this tech might replace the AAVs as the delivery vehicle of choice. That would be fine by me.

http://news.stanford.edu/news/2010/february1/longaker-stem-cells-020710.html

This next research report doesn't actually mention RNAi, but the comment at the end regarding minicircles is interesting:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892897/

"With its basic molecular principles and straightforward protocol, minicircle DNA is ideally suited for facilitating iPS cell research around the world. Finally, the minicircle DNA is already FDA approved, giving our novel method the potential for significant clinical translation."