RAC 3.15% $1.64 race oncology ltd

@Davisite reply function not workingAnother thing to consider is...

  1. 1,262 Posts.
    lightbulb Created with Sketch. 12397
    @Davisite reply function not working

    Another thing to consider is that there are significantly more writers increasing methylation within cells than erasers that demethylate. I realise the key methylators are METTL3 and METTL14, with information coming out about the unique role of METTL16. The other writers play more of a supportive role fascilitating the work of METTL3, METTL14, and METTL16.

    https://hotcopper.com.au/data/attachments/6216/6216037-d603256f2c04d10704bd03c3c1a8f284.jpg

    There is an enormous amount of available data supporting the relationship between depleted m6A levels and tumorigenesis. I put this table together this morning that highlights 287 gastric cancer patients with excellent follow-up information highlighting high FTO expression (low m6A) have 49.7% greater chance or mortality than low/medium FTO expression when all other factors are taken into account. FTO expression correlated with response and resistance to immune checkpoint blockade treatment as well as advanced cancer stages. FTO played such an important role in therapy response it is being considered a novel potential predictor and target for gastric cancers.

    https://hotcopper.com.au/data/attachments/6216/6216040-00405c5e5afc2f373a6ed9824601cbfc.jpg

    Also, for the first time ever, HER2 monoclonal antibody (Trastuzumab - Herceptin) resistance has been linked to decreased m6A levels (FTO overexpression / METTL3-METTL14 suppression). Increasing m6A levels increased sensitivity of resistant breast cancer cells to trastuzumab. This paper focused on METTL14 supression, but others will follow FTO overexpression in time. There is also the nice in vivo synergy between FTO KD and trastuzumab.

    https://hotcopper.com.au/data/attachments/6216/6216104-187d79e30cdef3a1d221a84e075701e0.jpg
    https://hotcopper.com.au/data/attachments/6216/6216111-ed3095e8f0d7ac16adb60d7ddf6b6b35.jpg

 
watchlist Created with Sketch. Add RAC (ASX) to my watchlist
(20min delay)
Last
$1.64
Change
0.050(3.15%)
Mkt cap ! $278.7M
Open High Low Value Volume
$1.58 $1.65 $1.57 $98.54K 60.86K

Buyers (Bids)

No. Vol. Price($)
2 2377 $1.59
 

Sellers (Offers)

Price($) Vol. No.
$1.64 320 1
View Market Depth
Last trade - 16.10pm 06/11/2024 (20 minute delay) ?
RAC (ASX) Chart
arrow-down-2 Created with Sketch. arrow-down-2 Created with Sketch.