just a bit of background reading
http://csmres.co.uk/cs.public.upd/article-downloads/Cipolla_2011-2012_Drug-Discovery-Today-Therapeutic-Strategies.pdf
Describes the benefits of inhaled delivery via metered dose.
"The inhalation route maximizes the delivered dose to the
respiratory tract while minimizing the dose delivered to the
rest of the body where it may serve no useful purpose and has
the potential to cause side effects. Inhalation delivery is
therefore more often superior for the treatment of respiratory diseases than other routes of administration"
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