Disappointment, unbelief.
https://en.wikipedia.org/wiki/Orphan_drug
QUOTE An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease. IN THE US AND THE EU it is EASIER TO GAIN MARKETING APPROVAL FOR AN ORPHAN DRUG, and there may be other financial incentives, such as extended exclusivity periods, all intended to encourage the development of drugs which might otherwise lack a sufficient profit motive. UNQUOTE
They can scrap the EU from that list now, the ema is failing to deliver on its orphan drug promises to patients and eu citizens.
Disappointment,...
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