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fumoyoda

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29/08/19

08:53

Post #: 40210048
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Originally posted by fumoyoda: ↑

https://www.degruyter.com/view/j/bmte.ahead-of-print/bmt-2015-0053/bmt-2015-0053.xml

download the pdf testing on mice

Conclusions
The results presented here show that SPMR technology can be used to specifically identify different types of Ab and cancer cell lines through incubation measurements. These same measurements also show that unbound NPs do not give a SPMR signal falling in the measurement time window. The measured sensitivity for breast cancer cells is orders of magnitude greater than a mammogram, and the specificity of the conjugated NPs is such that benign tumors will not be targeted. These facts, along with the observation that the decaying magnetic fields are trans-parent to tissue and bone and that the observed magnetic moments are linear with cell number, make SPMR an ideal method for application to cancer detection and treatment monitoring. Using PrecisionMRX™ NPs, a lower detection limit of 10,000 cells was measured in vitro at a distance of 4.5 cm from the detector. This represents an improvement of 2 orders of magnitude in the detection sensitivity of SPMR achieved with commercially available NPs reported previously [11].The ability to detect human cancer cells in animal models with great sensitivity is a precursor to taking SPMR methods to human tumor detection and localiza-tion. The results of these pre-clinical animal experiments are necessary to proceed toward approval of human sub-jects. The measured high sensitivity with the new NPs and SQUID sensors indicates that clinical applications of SPMR will have a high impact. The localization capability measured in the animal model also indicates that tumors can be localized in clinical settings sufficiently accurately for therapeutic applications

meanwhile not much movement except testing lows again today, considering their well presented results and plans.

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traceability for this article was from https://precisionmrx.com/2015/07/27/publication-magnetic-relaxometry-as-applied-to-sensitive-cancer-detection-and-localization/

from

https://precisionmrx.com/category/updates/

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0 Great analysis

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