Ionis gains approval on Tofersen in Europe overnight. Very good news as this is also a second-generation antisense oligonucleotide (as ATL1102). This one is also for a rare disease ALS
Tofersen is all about mediating mRNA degradation to prevent SOD1 protein synthesis and reduce levels of SOD1 protein.
A nice precedent for ATL1102.
https://www.prnewswire.com/news-releases/ionis-announces-european-medicines-agency-accepts-marketing-authorization-application-of-tofersen-to-treat-rare-genetic-form-of-als-301694129.html
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