When I listen to this excellent video, the most important thing...

When I listen to this excellent video, the most important thing in my mind is that the "primary outcome measure" in both current ph 2 studies is iron content in the brain, just the thing that was found to be connected to cognition in many different ways. They even found a likely reason why hypertension is a risk factor in the development of dementia or worsening of cognition, it is also iron!

When we are looking at what preclinical studies ATH has been doing, we find that "To date, we have performed in vivo evaluations of our product candidates in a range of animal models of disease including parkinsonian disorders, Alzheimer’s disease, Huntington disease, brain cancer, and traumatic brain injury". I think that any vascular stroke can be included in the category of traumatic brain injury.
Then we have the eye studies by Professor Finkelstein, perhaps targeting iron accumulation in eye diseases.

So only now it is clear that good neural function does not stand iron overload and at this moment it looks evident that ATH434 is a safe iron chelator. We hope that ph 2 studies will demonstrate this as it is the "primary outcome" of these studies. If ATH434 lowers the iron content in these studies it will open the gates to all these other indications: strokes, brain injuries, AD, HD, etc., and even hypertension as a risk factor for dementia.