ATH

0.00%

0.5¢ alterity therapeutics limited

Thanks Pivalde.After reading the full paper, which is an omnibus...

First 3 Last

Share
Profile

Follow
gumboot

382 Posts.

19

16/10/21

17:38

Post #: 56851074
Share
Originally posted by pivalde: ↑

Iron as the concertmaster in the pathogenic orchestra playing in sporadic Parkinson’s disease | SpringerLink

This paper tells "everything" how iron plays a central role in PD pathology. So it is a good paper to read if you want to understand why iron chelation by ATH434 could work in helping PD patients. It is not written by the top scientist of neurodegeneration but it tells IMO the most central issues.

The halfway conclusions were:

IRON increases with age.
IRON transfer through BBB is increased.
IRON export from brain is increased.
IRON is increased in SN blood vessels.
IRON storage by ferritin and neuromelanin is dysregulated.
Free/labile IRON increases and induces Fenton reaction leading to toxic hydroxyl radicals.
Ferroptosis causes proteasomal defect, mitochondrial disturbances and cellular cytotoxic processes, lysosomal defects, apoptosis and autophagy dysregulation, all together causing cell degeneration. Ferroptosis is characterized by an accumulation of lipid hydroperoxides (Dixon Scott et al.2012). The sensitivity to ferroptosis is linked to numerous biological processes and in particular to iron, glutathione, phospholipid, NADPH, coenzyme Q₁₀and polyunsaturated fatty acid metabolism (Yan and Zhang2020; Stockwell et al.2017). A deficient regulation of ferroptosis has been found in MPTP-treated mice (Tapias2019), a model of PD pathology (Fig.3).

But there is more when you continue after these conclusions including a very long list of references.
It is easy to agree with the final conclusions in the abstract:
"iron" is a major player in the pathology of PD. Selective chelation of excess iron at the site of the substantia nigra, where a dysfunction of the BBB is suggested, with peripherally acting iron chelators is suggested to contribute to the portfolio and therapeutic armamentarium of anti-Parkinson medications.

Now ATH needs to present that ATH434 works also in human PD. I would think that the primate study will come before that and most likely it is already going on somewhere.

Expand

Thanks Pivalde.
After reading the full paper, which is an omnibus of papers, I hope someone with more smarts than me can confirm it's relevance,
inasmuch as it convincingly links Fe with movement disorders and even throws in Fe in Covid 19
ATH Price at posting: 3.2¢ Sentiment: Hold Disclosure: Held
3 Upvote

0 Great analysis

Reply

There are more pages in this discussion • 1 more message in this thread...

First 3 Last

Add ATH (ASX) to my watchlist

(20min delay)
Last 0.5¢		Change 0.000(0.00%)		Mkt cap ! $26.22M

Open	High	Low	Value	Volume
0.5¢	0.5¢	0.5¢	$67	13.44K

Buyers (Bids)

No.	Vol.	Price($)
44	40123044	0.5¢

Sellers (Offers)

Price($)	Vol.	No.
0.6¢	17787904	20

View Market Depth

No.	Vol.	Price($)
44	40123044	0.005
37	59998681	0.004
46	44678315	0.003
15	32943014	0.002
14	98270102	0.001

Price($)	Vol.	No.
0.006	17787904	20
0.007	18189670	20
0.008	15299321	18
0.009	7171000	8
0.010	2700066	4

Last trade - 16.10pm 24/05/2024 (20 minute delay)


Last 0.6¢		Change 0.000 ( 10.0 %)
Open	High	Low	Volume
0.5¢	0.6¢	0.5¢	4997767
Last updated 15.10pm 24/05/2024 ?

ATH (ASX) Chart

Thanks Pivalde.After reading the full paper, which is an omnibus...

Featured News

PlaySide to take gamers back to Westeros with new PC title

Talisman expands Rip n Tear with lead grading 7.4% and silver at 59.2g/t in NSW

AIC Mines raises $57m to extend Eloise copper mine lifecycle

The Telstra twist - What the job cuts decision mean for investors?

Webinar: What investors should know about what it takes for ASX-listed companies to get medical developments to market

Yandal lines up prime gold targets at Ironstone Well-Barwidgee

Market Update: Energy the sole green sector as dull US mood sours Friday down under

Week 21 Wrap: NVIDIA's profits are up 600% – but this time, the market didn't really care

Nimy seeks massive sulphide systems through surveying at WA prospects

Althea on a high as it opens cannabis drinks in the US with Flora Growth

Buyers (Bids)

Sellers (Offers)

Featured News

Thanks Pivalde.After reading the full paper, which is an omnibus...

Featured News

Top Stories

PlaySide to take gamers back to Westeros with new PC title

Talisman expands Rip n Tear with lead grading 7.4% and silver at 59.2g/t in NSW

AIC Mines raises $57m to extend Eloise copper mine lifecycle

The Telstra twist - What the job cuts decision mean for investors?

Webinar: What investors should know about what it takes for ASX-listed companies to get medical developments to market

Yandal lines up prime gold targets at Ironstone Well-Barwidgee

Market Update: Energy the sole green sector as dull US mood sours Friday down under

Week 21 Wrap: NVIDIA's profits are up 600% – but this time, the market didn't really care

Nimy seeks massive sulphide systems through surveying at WA prospects

Althea on a high as it opens cannabis drinks in the US with Flora Growth

Buyers (Bids)

Sellers (Offers)

Featured News