I have always believed that AOD would only work by getting into...

I have always believed that AOD would only work by getting into the blood (ie systemic). The POH formulation has been designed to avoid this, so I guess people aren`t coming back for more. Problem we have there dosen`t seem to be any urgency to prove the theory from CZD for use of AOD as a nutraceutical or food additive since the GRAS was conditionally granted. At some point a trial will need to be conducted to verify the 90% statistic in the failed pharmaceutical trial. A simple trial on the most effective sub group (post menapausal women) at .05mg to 1mg including a placebo would give CZD something to offer possible partners.
As it stands time goes by with the patent depreciating in value every day with nothing on the horizon to answer the fundamental question

Cheers