Back in December 2013 Tewkleberry wrote:
"We're now 4 mths past the date that I referred to back in August that was likely to be the endpoint with no efficacy advantage. Even allowing for shortcomings** in the model I used, it's becoming a fairly compelling extension beyond expected FOLFIRI efficacy.
To borrow from P.Keating... "that's a beautiful set of numbers"
**One shortcoming is that we can't assume the shape of the FOLFHAIRI Kaplan Meier curve is the same as FOLFIRI. It is possible to have a long PFS tail causing a prolonged trial, but a similar median PFS. But the KM curve would need to be very distorted to extend this long "
Based on your previous analysis Tewk, is a distortion in the KM curve anyway possible now?
Thanks Fly
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