KZA Media Thread, page-1396

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novogenbuyer

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09/05/21

23:41

Post #: 53051047
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Originally posted by Rich&Poor: ↑

Thank you onesurfed, now a better understanding of GBM from this publication using animal studies using gene analysis.
"In our animal glioblastoma models, treatment with drugs targeting PI3Kγ consistently resulted in impressively durable responses to chemotherapy,"
The invitational GBM AGILE pivitol registration study arm for paxalisib in humans, should show similar results as published in phases 1 and 2 from both Genentech and Kazia trials.

We have previously discussed the ability of paxalisib to inhibit (deactivation) of all 4 isoforms of the PI3K protein.
"The key to curing this cellular "Stockholm syndrome" and possibly glioblastoma lies in a protein called phosphoinositide-3-kinase gamma isoform (PI3Kγ). Activation of this protein turns microglia and macrophages from immune cells that police cancer growth into hostage cells that promote cancer growth. Varner has studied this process for many years and pioneered drugs that restore the anti-tumor activities of microglia and macrophages".Looking forward to the first interim data release for GBM AGILE, and management's early response to the FDA.

Regards.

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This is great news to hear. The consistency of data coming from multiple unrelated researchers really strengthens the case for paxalisib to not only become the next standard of care, but to remain as a core part of any future combination therapy for such cancer patients. Very encouraging both from the standpoint of cancer patients as well as from the standpoint of a Kazia investor.

KZA Price at posting: $1.36 Sentiment: Buy Disclosure: Held
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KZA Media Thread, page-1396

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