KZA Media Thread, page-1767

Ok - @peterkins22 has sparked an interest in chickens that I didn't know I had - I think this is what your referring to:

"..Ketogenesis and Glioblastoma
Cells in the human body generally rely on glucose as ‘fuel’ for their energy requirements.
However, when glucose is not readily available, cells can metabolise fats and proteins to
provide energy. The fats and proteins are broken down to an intermediate form known as
ketones, and so this biochemical pathway is referred to as ‘ketogenesis’.
Unlike healthy cells, most tumour cells are poorly able to metabolise ketones, and so
depend on glucose for their energy needs. Consequently, many researchers have
experimented with ‘ketogenic diets’ as a potential treatment for cancer.1
In addition, scientists in Professor Cantley’s lab have shown that insulin has the potential to
counteract the anti-tumor effects of PI3K inhibitors.2
Insulin is a hormone produced by the
body in response to high levels of glucose. When the body is in a state of ketosis, glucose is
absent, and so insulin falls to very low levels.
For these reasons, there is a sound rationale to explore a combination of ketogenic diet and
paxalisib in glioblastoma. In this study, patients will also receive metformin, a common antidiabetic drug, which will help to further lower insulin levels...."

I had an uncle on a restricted diet many years ago with cancer - he managed to stay alive for about 2 years longer than prognosed - obviously diet studies are not new then but I guess to possibly increase the efficacy of Paxalisib, (GDC-0084) was easier for me to remember ), this study may well be warranted given the GBM focus. Not sure though where the chickens come into it?