KZA Media Thread, page-1843

https://thehill.com/video/administration/592595-watch-president-biden-reignites-cancer-moonshot-initiative?jwsource=cl

https://www.cancer.gov/research/key-initiatives/moonshot-cancer-initiative


For years, Dr. Yung and his team have been studying treatment options for patients with Glioblastoma multiforme (GBM) –the most deadly type of brain cancer – with an average 18-month lifespan after diagnosis. Dr. Yung is focused on drugs that target a gene called PI3K, which is a key factor in about 30% of GBM cases. His team collected glioma stem cells (GSCs) from GBM patients and developed a special panel of cell lines to investigate patterns of resistance to P13K inhibitors. The researchers are figuring out the molecular profile of these GSCs to identify potential targets for drug development. Results from the P13K studies have shown that the molecular profile of GSCs contain increased levels of Wee-1, which is a protein that controls cell division and growth. Following these results, the team then combined a P13K inhibitor with a Wee-1 inhibitor and found there was a greater inhibition of cell growth and the cancer cells were induced into cell suicide. Plus, when they tested the same inhibitors on complex GBM tumor models, they discovered similar benefits. These findings reveal molecular targets and designs for combination therapies that could lead to new treatments for GBM patients. Earlier in his career, Dr. Yung led the study that paved the way for FDA approval of temozolomide (Temodar®) for GBM and led the registration study that preceded FDA approval of the drug bevacizumab (Avastin®) for recurrent GBM.

https://profiles.gulfcoastconsortia.org/profilesystem/editprofile.php?pid=2100#4

Maybe paxalisib could be tested with a Wee-1 inhibitor?

Regards.