This is again another AIBL study by Masters and Bush et al.Elucidating the Link Between Anxiety/Depression and Alzheimer's Dementia in the Australian Imaging Biomarkers and Lifestyle (AIBL) Study
AffiliationsDOI: 10.1007/s44197-024-00266-w
- PMID: 38896210
Abstract
Background: The associations between mood disorders (anxiety and depression) and mild cognitive impairment (MCI) or Alzheimer's dementia (AD) remain unclear.
Methods: Data from the Australian Imaging, Biomarker & Lifestyle (AIBL) study were subjected to logistic regression to determine both cross-sectional and longitudinal associations between anxiety/depression and MCI/AD. Effect modification by selected covariates was analysed using the likelihood ratio test.
Results: Cross-sectional analysis was performed to explore the association between anxiety/depression and MCI/AD among 2,209 participants with a mean [SD] age of 72.3 [7.4] years, of whom 55.4% were female. After adjusting for confounding variables, we found a significant increase in the odds of AD among participants with two mood disorders (anxiety: OR 1.65 [95% CI 1.04-2.60]; depression: OR 1.73 [1.12-2.69]). Longitudinal analysis was conducted to explore the target associations among 1,379 participants with a mean age of 71.2 [6.6] years, of whom 56.3% were female. During a mean follow-up of 5.0 [4.2] years, 163 participants who developed MCI/AD (refer to as PRO) were identified. Only anxiety was associated with higher odds of PRO after adjusting for covariates (OR 1.56 [1.03-2.39]). However, after additional adjustment for depression, the association became insignificant. Additionally, age, sex, and marital status were identified as effect modifiers for the target associations.
Conclusion: Our study provides supportive evidence that anxiety and depression impact on the evolution of MCI/AD, which provides valuable epidemiological insights that can inform clinical practice, guiding clinicians in offering targeted dementia prevention and surveillance programs to the at-risk populations.
https://link.springer.com/article/10.1007/s44197-024-00266-w
- Forums
- ASX - By Stock
- ATH
- Link Between Anxiety/Depression and Alzheimer's Dementia
Link Between Anxiety/Depression and Alzheimer's Dementia
Featured News
Add ATH (ASX) to my watchlist
(20min delay)
|
|||||
Last
0.4¢ |
Change
0.000(0.00%) |
Mkt cap ! $21.28M |
Open | High | Low | Value | Volume |
0.4¢ | 0.4¢ | 0.3¢ | $6.732K | 2.155M |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
35 | 17158898 | 0.3¢ |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
0.4¢ | 130236053 | 30 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
35 | 17158898 | 0.003 |
66 | 88703179 | 0.002 |
30 | 141210102 | 0.001 |
0 | 0 | 0.000 |
0 | 0 | 0.000 |
Price($) | Vol. | No. |
---|---|---|
0.004 | 130236053 | 30 |
0.005 | 19048455 | 23 |
0.006 | 22089363 | 18 |
0.007 | 54073650 | 25 |
0.008 | 42418463 | 31 |
Last trade - 16.10pm 07/10/2024 (20 minute delay) ? |
Featured News
ATH (ASX) Chart |