This new review paper from Parkville, Melbourne focuses on lipids, small extracellular vesicles in AD which may have an important role in the pathogenesis of AD and can perhaps be also used as a biomarker of AD. The list of 311 references demonstrates that there is something very interesting but not yet anything specific to us, ATH investors, however. This is a paper for those who are interested in AD pathogenesis and it is a free paper to read. Here is the abstract.

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Review

Proteomics

. 2023 Aug 31;e2300063.

doi: 10.1002/pmic.202300063. Online ahead of print.

Exploring the significance of lipids in Alzheimer's disease and the potential of extracellular vesicles

Huaqi Su ^{1 2}, Colin L Masters ¹, Ashley I Bush ¹, Kevin J Barnham ¹, Gavin E Reid ^{2 3}, Laura J Vella ^{1 4}

Affiliations expand

• PMID: 37654087

DOI: 10.1002/pmic.202300063

Abstract

Lipids play a significant role in maintaining central nervous system (CNS) structure and function, and the dysregulation of lipid metabolism is known to occur in many neurological disorders, including Alzheimer's disease. Here we review what is currently known about lipid dyshomeostasis in Alzheimer's disease. We propose that small extracellular vesicle (sEV) lipids may provide insight into the pathophysiology and progression of Alzheimer's disease. This stems from the recognition that sEV likely contributes to disease pathogenesis, but also an understanding that sEV can serve as a source of potential biomarkers. While the protein and RNA content of sEV in the CNS diseases have been studied extensively, our understanding of the lipidome of sEV in the CNS is still in its infancy.