Copper, sorry but I just don't spent much time on your posts. Regarding the efficacy seen in Reach2HD, perhaps you should read up on the importance of TMTB over say TMTA. Read which measure is changing right before onset. You and others seem to think the measures are all equal. They are not, from what I have read. The truth is that a pre specified endpoint reached stat sig. There is no way to talk around that scientific fact, and it is a very important measure to HD carriers facing onset.
LLY change at the top., page-13
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