macrocyclic drugs to unlock new targets, page-7

Tony,
From the conclusion of participants in the SciBX Summit;
"Cracking the code for cell permeability was pegged as a critical advance needed to propel the field forward."

Escaping the endosome is key; if the data to be presented at conference on the Endosomal Escape Trap technology demonstrates that Phylogica has 'cracked the code' then the interest in the platform will be heightened. Looking at the participants in the Summit, we see that Peptidream and Aileron were represented; the Summit task force included Tomi Sawyer.

Look at this comment;
"An additional benefit to understanding the rules would be the ability to bias screening libraries so they contain more molecules likely to be cell permeable or have other desired pharmacological properties."

This is currently the focus of the technology value adding milestones. If the milestones are reached, Phylogica is on the cusp of a major breakthrough.

Wayne.