Tony,
Another comment which caught my attention;
"Even less is known about active transport via endocytosis, although this mode of cell permeability will almost certainly be required for larger members of the macrocycle class to get into cells."
From the Boston Tides presentation;
"Virus exploit all major endocytotic pathways for cell entry". Phylogica can screen for invasive pathogens which it describes in the presentation as a 'rich source of natural CPPs'.
The buzz phrase which is used is "nature has solved the problem of cell penetration and endosomal escape'. Herein lies the reason why Phylogica has the opportunity to be successful in resolving the conundrum of cell permeability.
Wayne.
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