Study determines frequency and patterns of T-cell escape mutations in HIV patients undergoing antiretroviral therapy
The findings also suggest the majority of these immune cells, called CD8+ T cells, should have the capacity to detect the HIV-infected cells that drive HIV-1 rebound following interruptions to treatment. This insight could contribute to the development of new curative strategies against HIV infection.
"Our findings show that the majority of HIV-1-specific T cells in people on ART can detect HIV viruses that have the capacity to rebound following treatment interruption," concludes senior author Nilu Goonetilleke, a faculty member at the Department of Microbiology and Immunology, University of North Carolina at Chapel Hill."This suggests that T cells likely help to control viral rebound and could be leveraged in future treatment strategies against HIV."
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