Since both Vaxinia and Oasis trial are dose escalating with toxicity as the primary endpoint, is it possible that the FDA will allow us to move onto patients before they have been ravaged by chemo and have healthy immune systems down the track? Could the registrational trials be conducted on healthier patients? A simple blood test could screen for healthy immune systems. It might slow down our progress whilst we wait for healthier candidates but will provide a better window into the likely success of our treatments.
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