There are various approaches for incorporating yttrium-90...

There are various approaches for incorporating yttrium-90 radioembolization in the overall treatment plan for metastatic colorectal cancer patients, and I believe this study lends support to first-line delivery concurrent with systemic chemotherapy. Use during a ‘chemo holiday’ also remains appropriate as well. Candidates for yttrium-90 should have limited extra-hepatic disease, total bilirubin less than 2.0 mg/dL, and reasonable functional status.

http://www.radiologyreport.org/radioembolization-of-metastatic-colorectal-cancer/