R&P- Nice of you to change the date "Labman" originally posted....

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onesurfed

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31/07/22

22:25

Post #: 62842088
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Originally posted by Rich&Poor: ↑

2nd Annual Conference on CNS Clinical Trials and Brain Metastases
11:00-13:00 Friday, 12 August, 2022MMAP-05:
Phase I study of concurrent paxalisib and radiation therapy in patients with solid tumor brain metastases or leptomeningeal metastases harboring PI3K pathway mutations: results from the dose-escalation cohort -- Jonathan Yang, Memorial Sloan Kettering Cancer Center.

LabMan - latest post on disallowed also confirms our latest paxalisib discussions.

"Low float company belies the broad interest in this pAX with radiation therapy, PIK3CA brain mets trial, at MSK. Confirmation of MTD & expansion cohort commencement results, at SNO on 12 August. mTOR/PI3K/AKT signaling is the primary upregulated mechanism seen to cause radiation treatment resistance. The trial carries a higher risk profile, but evidence of pathway radiosensitization, has implications for cancer treatment. The expansion will enroll an additional twelve patients to explore efficacy. Radiotherapy has a central role in the treatment of many cancers PI3K/AKT/mTOR pathway sensitization has not been conclusively established, in previous studies. Mutations in PTEN, AKT or the mTOR complex are known to be enhanced by radiation, causing activation of the PI3K/AKT/mTOR pathway, resulting in cancer cell growth and proliferation. The know safety profile, dual pathway, pan inhibitor paxalisib is said to be the premier drug in this class".

Regards.

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R&P- Nice of you to change the date "Labman" originally posted. That mistake adds to my suspicions that "Labman" is an info-aggregator program, as a real person who keeps track of Kazia would not have made it. Other evidence consists of 1) the manner of speech and 2) "Labmans" failure to respond to any questions put to "him".

A sufficient source of information for "Labman" would be the media thread of HC. I'd give more credit to posts with foresight than those which just consist of re-arranged words of other posters. Just a bone I have to pick with "Labman", actually irrelevant here, carry on.

KZA Price at posting: 51.0¢ Sentiment: Buy Disclosure: Held
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