15 June...

15 June 2020

https://academic.oup.com/ndt/article/doi/10.1093/ndt/gfaa084/5857810

Midkine and chronic kidney disease–associated multisystem organ dysfunctions

This review summarizes the growing body of evidence supporting MK’s potential role in driving CKD-related multisystem disease, including MK’s relationship with the endothelial glycocalyx, the deranged MK levels and glycocalyx profile in CKD patients and a proposed model of MK organ interplay in CKD disease processes and highlights the importance of ongoing research into MK’s potential as a therapeutic target.

Victoria K Campbell, Ryan P Gately, Rathika Krishnasamy, Dominic Burg, Graham R Robertson, Nicholas A Gray