https://www.labroots.com/trending/cardiology/18028/discovering-si...

https://www.labroots.com/trending/cardiology/18028/discovering-signal-junction-controlling-pulmonary-arterial-hypertension

Discovering a New Signal Junction Controlling Pulmonary Arterial Hypertension

"...
To sum it all up, under hypoxic conditions, the cell would produce nucleolin at the cell surface. Midkine would then bind to it and activate the EGFR signaling pathway. The EGFR pathway would then go on to cause the muscularization of blood vessels by migrating PASMCs to the blood vessels.

This is quite an interesting discovery. This study not only identified a connection between midkine, nucleolin, and EGFR, but it showed it was also a possible drug target. By inhibiting the midkine interaction with nucleolin, it could prevent EGFR signaling.

This would effectively halt the muscularization process and prevent PAH. While further research is needed, the idea of a simple drug that could treat or prevent PAH is quite a find.
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