In cases where avian influenza viruses have directly infected people, human-to-human transmission have taken place. Genetic re-assortment may result in new viruses that can be transmitted between humans. This could result in a human influenza pandemic. A pandemic is a global outbreak of disease. In the 20th century this has been documented 3 times.
1918 (H1N1) - "Spanish Flu". Caused the highest number of known flu deaths. 20-50 million people may have died worldwide.
1957 (H2N2) - "Asian Flu"
1968 (H3N2) - "Hong Kong Flu"
migratory risks huge, page-17
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