Great write up kpax - it's very good timing as we head into MND trial kickoff to be reminded of the science. After all, it's ultimately what we're invested in!
It seems that as the collective knowledge around neurodegenerative diseases expands, the evidence implicating mTOR and its role in up and down regulating cellular metabolism and autophagy continues to strengthen.
I would not be at all surprised to find MPL has efficacy in more than one neurodegenerative disease - Parkinson's looks like a decent candidate, as does muscular dystrophy.
Roll on MND trial commencement and some evidence of efficacy - that vital proof of concept.
Cheers
Densy
MND Phase 1/2/3 Trial review what to expect. The Chemistry !, page-2
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