Molecular iron related mechanisms in AD and drug targets, page-2

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pierre77

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05/10/22

21:01

Post #: 64049903
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Originally posted by pivalde: ↑

This paper explains the role of iron and ferroptosis in AD and also gives an understanding of the potential therapeutic possibilities as iron chelators, lipid peroxidation inhibitors, flavonoids, polyphenols, etc.

This paper is not for everybody, but it is free for those interested.
Review

.2022 Sep 16;13:983623.
doi: 10.3389/fphar.2022.983623.eCollection 2022.
Iron dyshomeostasis and ferroptosis in Alzheimer's disease: Molecular mechanisms of cell death and novel therapeutic drugs and targets for AD
Yuan Zhang¹, Man Wang¹, Wenguang Chang¹
Affiliations
PMID:36188557
PMCID:PMC9523169DOI:10.3389/fphar.2022.983623
Abstract
Alzheimer's disease (AD) is a degenerative disease of the central nervous system that is the most common type of senile dementia. Ferroptosis is a new type of iron-dependent programmed cell death identified in recent years that is different from other cell death forms. Ferroptosis is induced by excessive accumulation of lipid peroxides and reactive oxygen species (ROS) in cells. In recent years, it has been found that ferroptosis plays an important role in the pathological process of AD. Iron dyshomeostasis contribute to senile plaques (SP) deposition and neurofibrillary tangles (NFTs). Iron metabolism imbalance in brain and the dysfunction of endogenous antioxidant systems including system Xc- and glutathione peroxidase (GPX) are closely related to the etiopathogenesis of AD. Dysfunction of nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy induced ferroptosis can accelerates the pathological process of AD. In addition, NRF2, through regulating the expression of a considerable number of genes related to ferroptosis, including genes related to iron and glutathione metabolism, plays an important role in the development of AD. Here, we review the potential interaction between AD and ferroptosis and the major pathways regulating ferroptosis in AD. We also review the active natural and synthetic compounds such as iron chelators, lipid peroxidation inhibitors and antioxidants available to treat AD by alleviating iron dyshomeostasis and preventing ferroptosis in mice and cell models to provide valuable information for the future treatment and prevention of AD.

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Hi Pivalde,

whats your view on the latest Biogen study :

“ In the Phase 3 study, the drug called lecanemab removed built-up plaque in the brain called beta amyloid. Importantly, this also led to a cognitive benefit for patients with early-stage Alzheimer's disease”.
ATH Price at posting: 1.3¢ Sentiment: Buy Disclosure: Held
1 Upvote

0 Great analysis

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