Bit of the mystery solved after several calls and a couple of favours called in. Lots of details on how they are collected and calculated.
IMS numbers are on volume only when Dr R quotes em. No ifs no buts.
Differing brokers numbers where they place a value on it are because of their models and taking averages / knowns in regards to rebates , chargebacks, subsidy, package costs in to account. Guestimates and variables.
I was especially warned that there is a significant difference between the gross headline market $ size for a molecule quoted and the real $ net value achieved. Sort of like calculating a market $ value using a RRP times volume achieved and not including volume discounts , monthly rebates, value rebates etc etc.
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