ASX Release
Avexa’s ATC demonstrates activity against emerging
class resistance
30 November 2007
Biotechnology company Avexa Limited (ASX:AVX) announced today that a series of in-vitro experiments have
shown that ATC maintains potent antiviral activity against strains of HIV which are resistant to the new class of
integrase inhibitors, including the recently approved Merck HIV integrase inhibitor, raltegravir.
Resistance to raltegravir and to elvitegravir (Gilead’s integrase inhibitor, presently in clinical trials) has already been
shown to develop in patients, and could emerge as a significant problem. Furthermore, mutations in the virus that
give rise to raltegravir resistance also result in resistance to elvitegravir. Data from clinical trials with both raltegravir
and elvitegravir have shown that these drugs work best if they can be used together with another drug which retains
full activity. For patients who have already been treated with many of the existing drugs on the market, finding such
fully active drug ‘partners’ can be difficult.
On the eve of World Aids Day CEO, Dr Julian Chick said,
“These results underscore the importance that ATC could hold for patients in enabling them to achieve a new drug
regimen comprising three fully active drugs.�
“The addition of ATC could play a very important role in supporting and enhancing other new drugs such as
integrase inhibitors, and making the best use of them. ATC’s excellent safety profile and ease of dosing further
enhance its importance as a pivotal component of the HIV treatment armamentarium � he said.
Avexa announced today that full 24 week data from its apricitabine (ATC) Phase IIb trial has been accepted for
presentation at the 2008 Conference on Retroviruses and Opportunistic Infections (CROI). One of the most
prestigious meetings of its kind, CROI gathers scientists and clinicians working at the forefront of HIV drug
discovery, research and treatment and provides a forum to share and discuss the findings of their work. The 2008
meeting of CROI will be held in Boston, USA, between the 3rd and 6th of February 2008.
The Company expects to initiate the Phase III program for ATC by the end of this calendar year and is expecting
the 48 week data from the Phase IIb study to be released in the first quarter of 2008.
For more information:
Dr Julian Chick Dr Jonathan Coates Dr Susan Cox Mr Rod North
Chief Executive Officer Chief Scientific Officer Head of Development Bourse Communications
+61 3 9208 4300 +61 3 9208 4300 +61 3 9208 4300 + 61 3 9510-8309
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