cbdont think the issue of once v twice daily is quite as simple...

cb
dont think the issue of once v twice daily is quite as simple as that... or as some simple minded may think

hey P

sure, likely to miss a dose more often with a twice daily requirement

but, the impact of a missed dose is much bigger in a once daily...

"The pharmacokinetic consequences of missing a single dose in a once-daily regimen is similar to those of missing three consecutive doses in a twice-daily regimen. Such a delay is observed almost twice more often in once-daily than in a twice-daily dosing regimen."
http://www.hivpresentation.com/assets/A287B17D-E0C4-D510-0FB37C6FB93C9A74.PDF