Here is an article talking about significant results for the...

Here is an article talking about significant results for the reduction of viral shedding (yes I'm aware it is written by a potential competitor talking about GEN-003). I don't know enough about this stuff to argue the point but it made me question the companies expectations, and not for the first time. Make of it what you will.

https://liveherpesvaccine.com/2016/09/30/gen-003-yet-more-dragon-slaying-research/

In terms of HSV-2 virus shedding, a study would have to show a 5,000 to 10,000% reduction in HSV-2 shedding (50- to 100-fold) to achieve statistical significance at the p< 0.0001 level, and if GEN-003 vaccination elicited a 50- to 100-fold reduction in HSV-2 shedding, then they would not be leading with the “consolation prize argument” of achieving statistical significance at the p<0.05-level.
In practical terms, less than a 2.0-fold effect in science is generally a losing proposition, and a 1.0-fold effect is, by definition, “NO EFFECT” at all.  Real scientific discoveries that are worth talking about are generally based upon 5- to 500-fold effects.  The latest GEN-003 vaccine press-release reports that their therapeutic HSV-2 vaccine achieves a 1.7-fold reduction in HSV-2 shedding that is simply not worth discussing.