MPS - A tablet -v- subQ - The results before the test., page-2

PART 2 MPS - A TABLET -V- SUBQ - THE RESULTS BEFORE THE TEST


In part 1 we were introduced to an amazing study conducted back in 2016 full of amazing quotes that are profound as much as they are inspirational. Don't think that because it is some other animal it is automatically not to be applied to us. This is a real insight we are getting and it is applicable to humans...some answers before our final test.


I've told a few of my close friends about iPPS, not a single one of them I have fed with such graphic and granular details as I present to you tonight. Why? They would be bored of my science, of my details, they just want a stock that has some potential in the future, they will invest x and if they get something like 2x or 3x, well they are happy. They are all happy with their investment though some are a little under water at this very moment, but I occasionally remind them that we are on track and do not sell. This is NOT the stock that I want them to sell at 100% profit. Not advice. Paradigmers, I really do believe it is WE that are the informed investor, we have each other's backs, keep feeding us here at this forum, bring your questions, bring your thoughts, let's discuss, don't be shy. Don't fear that what you are asking is dumb....ask it anyway...it's all anonymous...you can only learn.





^{Possibly one of the most amazing studies I've read to date...thank you for the sacrifices of the three groups of dogs, your efforts could one day help literally thousands and has brought real insight into this reader/investor.}



Part 2 tonight we will uncover some more eye opening evidence of the marvellous effect of what YOU and I own...some of the science behind it will amaze you.


FURTHER RESULTS IN DETAILEFFECTS ON VASCULAR LESIONS

A lesion can be thought of as a capillary or venous malformations. (Mozz Speak? Well it's like the vein or artery is not wide and all smooth...it's either tighter, crumpled, deformed to some extent and it hasn't grown in the right way). In Dogs with MPS it has been well documented the consistency of the "pathological mechanisms contributing to the vascular lesions in the aortas of MPS I dogs" ¹. It was found that in the PPS treated dogs using high magnification showed "extensive storage vacuoles in the untreated dogs, and decreased vacuolation in the PPS-treated animals". Mozz speak again? Simply it means the walls of the observed vessels were thinner in the PPS treated dogs but were a lot wider in the untreated MPS dogs meaning that it is harder for blood to flow. Remember the 5 laned freeway.

Take a look at the following table, it's even more prolific... remember lumen is the inside space of a tubular structure...and thickness refers to the walls of the vessels, compare SQ PPS to Normal Dogs...





SQ PPS has a dramatic effect on bringing the results closer to normal..


Another example of the eamplory action of iPPS?

Plaque also formed on the walls in untreated MPS dogs which has the effect of disrupting the internal elastic lamina of the vessels. It was observed that:

"PPS-treated aortas showed almost intact elastin fibres without fragmentation".



THE DOG MODEL USED IN ERT AND OTHER OBSERVATIONS

The same study also mentioned the fact that the canine model of MPS I has been used extensively to develop ERT for MPS I patients. It's another clue that this is good evidence of high enough scientific justification that has actually been used in developing the ERT solution in humans, the same can possibly be extrapolated for iPPS observations into humans. As I have mentioned we already have some good evidence of the workings of iPPS in human patients, it was still quite an insight to read this report and it's findings.

The report also stated this:

"The dose used in this dog study (1.6 mg/kg) was based on previous MPS VI rat studies showing optimal effects at 2 mg/kg ".

The soon to be initiated dosing study will also no doubt test this theory to come up with the optimal dosing which we have always suspected is around the 2 mg/kg mark.

It was also reported that surprisingly (according to the study) PPS also prevented the elevation of cytokines in the CSF, particularly a bio marker known as IL-8. The subQ administration was more effective in this area due to the higher bio availability. They also speculated that more studies on the brain can be achieved particularly with MPS III, this may be the next frontier in the MPS domain after the Adelaide trial sometime in the future? If there are ways to use a catheter for example (to cross the blood brain barrier) as evidenced by the Mad Cow's (Creutzfeld-Jakob) manifestation in humans (see this post ----> PAR AND MAD COW'S ) this also, will be quite a find.

The study also mentioned there were some modest improvements in terms of vertebrae utilising microCT analysis but this was only noted in the subQ dogs. Due to "funding restraints" full MRI analysis wasn't carried out on the subQ dogs. It was suggested that there could be further modest improvements in the spinal pathology if subQ is administered for at least 2 years.

Interestingly this report also concluded that iPPS would be a good adjunct together with ERTs or as a stand alone treatment. It's ratifying when scientists also come to this conclusion as we have. A potential partnership of titans as I call it.

Finally the study also clearly stated that at no point in the entire two years of observation of any of the dogs were ANY adverse reactions detected along with ANY elevation of safety markers.



SUMMARY

PAR have released data on the MPS trial last year, yes it was great and it was on human patients. I sought out to bring you further evidence and some details we haven't heard or read about to date. Imagine the efficacy, actually being able to make a difference to vessels, enlarging them over all, thinning out the walls so that an increase of blood flow can take place. This not only staves off the chances of heart failure and stroke but it also expands the highways to deliver vital nutrients to the body of affected patients. This will take place over time and affect such critical areas as the heart, the lungs and perhaps the brain and central nervous system.

I personally feel over time (a few years) there will be more discoveries and reports on the amazing action of iPPS.
Paradigmers, this will translate to real revenue for us and it is not in 5 to 7 years time. It could well be within a year from now.




DISCLAIMERS

I somehow like the disclaimers section, can you tell? It's kinda like the movie has finished...[you know what movies I'm referring to....(Avengers and the other superheros)]....always wait till the end, there is a snippet, a clue to the next movie. While I don't give any clues to my next posts...it is fun to make these disclaimers interesting and deliberately non-legal despite my legal dept getting very cross with me.


Paradigmers, I'm no scientist, I just read the facts...the science...and I attempt to Mozzify^® it so we can all understand it (specially ME!). As always, don't go crazy...imagine something went wrong, invest in such a way so you will not lose the lot if the worst scenario played out.

I was never voted in to be on the island...but here I am and you get the brunt of my research. I feel compelled to share. I do not have some secret agenda...I do not directly profit if YOU buy or sell...I have been offered some lovely bottles of red (you know who you are) and I thank you guys sincerely but I cannot accept, your honest praise and encouragement, your support is more than enough. I love our company and I am amazed by what has been discovered and I'm even more amazed that no one....not a single person not a single entity has patented this and has struck a deal with Bene...we are the ones...

Yes there is good potential here in my views, it does not mean there won't be dips, it doesn't mean our share price won't be unusually low (though on tiny volumes) and that the road ahead won't be a long or bumpy one. Factor this in, be patient..the future could really work out well for us...and it's NOT years away.





REFERENCES

1] THE PEER REVIEWED STUDY: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827827/#__ffn_sectitle
2] https://www.sciencedirect.com/science/article/pii/B9780080548166000094
3] https://www.sciencedirect.com/topics/neuroscience/glycosaminoglycans
4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041195/
5] http://www.sickkids.ca/PlasticSurgery/What-we-do/Vascular-Anomalies-Clinic/Vascular-Malformations/Venous-Malformations/index.html#:~:text=Frequently%20Asked%20Questions-,Overview,coloured%20skin%20stain%20or%20swelling.
6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176785/#!po=11.5385
7] https://www.ncbi.nlm.nih.gov/books/NBK544295/#:~:text=Keratan%20Sulfate,-Keratan%20sulfate%20has&text=In%20conclusion%2C%20glycosaminoglycans%20(GAGs),%2C%20anticoagulation%2C%20and%20wound%20repair.
8] https://ghr.nlm.nih.gov/condition/mucopolysaccharidosis-type-i#genes
9] https://wagwalking.com/condition/mucopolysaccharidoses