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"An option to stop the trial for efficacy or futility - neither...

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    "An option to stop the trial for efficacy or futility - neither was demonstrated?"


    Overwhelming efficacy. It cannot be ruled out - even at the 45% readout - due to the way the trial is powered. We don't (and can't) have all of the necessary details to determine this, but this table by @omnisearch is a good graphical descriptor:
    https://hotcopper.com.au/threads/overwhelming-efficacy-the-stats-required.5579134/page-522?post_id=48623017

    You can almost certainly rule out futility of treatment.
 
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