Correct, I was asleep! But I did watch the MOA discussion from the ODAC meeting this morning. The MSB response reiterated that they clearly believe this therapy is not just a treatment for SR-aGVHD, but a treatment for a wide range of diseases involving systemic inflammation.
My point is that whether the MOA is, in fact, generalisable to other clinical applications beyond SR-aGVHD will have to be borne out in further clinical trials involving the treatment of other diseases. MSB have me convinced, and I desperately hope the results of future clinical trials for other applications (incl. for C-19-related ARDS) continue to support the theorised MOA!
MSB Trading 2020 - a new dawn, page-559
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