I would guess you have done your research but in case not, there is this titbit on wikipedia...
https://en.wikipedia.org/wiki/Nattokinase
Heart disease[edit]
Nattokinase may be potentially useful as a clot-buster and blood thinner, and is considered by some in the alternative medicine community as a possible adjunctive therapy in cardiovascular disease. There is some evidence for its effectiveness.[9][10][11][12][13][14][15][16][17] Possible side effects have been reported. In one case, a patient concurrently taking aspirin and 400 mg of nattokinase daily for seven consecutive days to prevent stroke suffered an acute cerebellar hemorrhage.[18]
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