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Need to push the IV dose higher, page-20

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    Yep, but this trial is using 48 hours as a dosing interval.

    Given that peak concentrations are already low, even if we are lucky enough to achieve a partly useful plasma concentration of say 600ppm in this trial (just above MIC of 2 out of 6 ESKAPE pathogens), concentrations are unlikely to remain that high for long enough.

    Repeat dosing every few hours, maybe. But that would need to be proven safe in another trial.

    .
    https://hotcopper.com.au/data/attachments/5577/5577987-1cf25613d639a943296b4942b41c78c8.jpg
    https://hotcopper.com.au/data/attachments/5577/5577989-d642ebf260c4c416e9f7146452d935c1.jpg
 
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