Australia's largest stock trading and investment forum Australia's #1 stock forum

RCE

Click for more information

1.09%

45.5¢ recce pharmaceuticals ltd

Need to push the IV dose higher, page-3

First 3 Last

Share
Profile

Follow
Gitmo

1,998 Posts.

311

19/10/22

15:55

Post #: 64281692
Share

Originally posted by reon1: ↑

From the phase 1 IV data released today, it looks as though the kidneys are clearing the 327 almost as quick as they can put it in! A total 1-hour infusion of 6,000mg for an 80kg man works out to be around 3,200ug of 327 per mL of plasma. Yet the peak concentration from the study is only 175ug/mL.

Previous pre-clinical work suggests we would want concentrations of 500ppm, and possibly up to 2,000ppm for certain bacteria.

I've plotted the plasma data in excel and selected the best fit trend line:

I really hope that management continue the current phase 1 trial to the original top dose of 16,000mg! Repeat doses may increase plasma concentrations slightly if intervals are short. But at this stage, it seems the kidneys are too efficient and a higher/faster dose may be worthwhile.

Anyone tune into webinar? Did they say what the time interval was between dosing and sampling for peak plasma concentration? Or were bloods taken literally at the end of the infusion?

Expand

I missed the webinar. Recording should be out by tomorrow

RCE Price at posting: 76.5¢ Sentiment: Hold Disclosure: Held
2 Upvote

0 Great analysis

Reply

Top Stories

ARN

Aldoro shares jump 47% on news of strong niobium recoveries from Namibia play

Week 28 Wrap: ASX hits all time high; CBA shares' two realities; US inflation hits 3% ahead of China plenum

I88

Infini soars 50% as company reveals it could’ve just made uranium history – redefining what it means to be “high grade”

Shekel Brainweigh and Calmer Co lead innovations in the retail space

RCE

Recce scores US$2M deal from US Department of Defense for burn wound infections gel

There are more pages in this discussion • 24 more messages in this thread...

First 3 Last

Add RCE (ASX) to my watchlist

(20min delay)
Last 45.5¢		Change -0.005(1.09%)		Mkt cap ! $100.9M

Open	High	Low	Value	Volume
46.5¢	48.5¢	45.5¢	$393.8K	852.0K

Buyers (Bids)

No.	Vol.	Price($)
6	134403	45.5¢

Sellers (Offers)

Price($)	Vol.	No.
46.0¢	37839	2

View Market Depth

No.	Vol.	Price($)
5	132403	0.455
11	209394	0.450
2	112000	0.445
6	176820	0.440
1	1500	0.435

Price($)	Vol.	No.
0.460	37839	2
0.475	863	1
0.480	124896	3
0.485	82243	1
0.495	110000	2

Last trade - 16.10pm 15/07/2024 (20 minute delay)

RCE (ASX) Chart

SPONSORED BY