From the phase 1 IV data released today, it looks as though the kidneys are clearing the 327 almost as quick as they can put it in! A total 1-hour infusion of 6,000mg for an 80kg man works out to be around 3,200ug of 327 per mL of plasma. Yet the peak concentration from the study is only 175ug/mL.
Previous pre-clinical work suggests we would want concentrations of 500ppm, and possibly up to 2,000ppm for certain bacteria.
I've plotted the plasma data in excel and selected the best fit trend line:
I really hope that management continue the current phase 1 trial to the original top dose of 16,000mg! Repeat doses may increase plasma concentrations slightly if intervals are short. But at this stage, it seems the kidneys are too efficient and a higher/faster dose may be worthwhile.
Anyone tune into webinar? Did they say what the time interval was between dosing and sampling for peak plasma concentration? Or were bloods taken literally at the end of the infusion?
(20min delay)