If you are new to Neuren then this is a very informative summary by Larry Glass given in 2019, an 'oldy but a goody', one might say. If you're not new, well...go on...you know you want to. Try from about 4:30min time stamp for the unpacking of 2591's role in furnishing the brain with enough IGF-1 to have microglia function fortified and managed to a homeostatic level similar to wild type individuals that are otherwise unaffected by gene deletion or synaptopathies typical of rare diseases we now know so well.
If you are new to Neuren then this is a very informative summary...
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