Wheres can this UPI article be found that everyone keeps referring to??
The Drudge report times out.
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neuren pharmaceuticals limited
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Neuren - where to from here ?, page-70
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These guys absolutely suck. I'm sick of them, they are a cancer on the Earth. Do not let them in what ever you do. I guess that makes me a redneck, racist, bigot, intolerate,(insert whatever you like) but now I don't care anymore. THey can all f#@%k off....
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Metals & Mining SECTOR NEWS
Global Rights to Transformative Technology for PV Solar Cell Recycling Secured
18 Jun 2025 LITHIUM UNIVERSE LIMITEDLU7 acquires global rights to transformative PV recycling technology from Macquarie University, targeting higher material recoveries from solar waste and backed by $1.7M in investor commitments. The technology... Read more
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Sharenot so stupid now Up 10% Gobs baby, when's the big sell off due? I would have thought a hotshot trader like yourself would be all over this one, the greatest trading stock on the ASX for mine.
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Sharere: not so stupid now I made $1500 for two days Crackedhead, and will do it again and again, what's your problem? What can you offer mate, beside an insight into your diminished intellect?
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Sharere: not so stupid now Yeah, right peanut, aren't you the mega trader? Pity you have no credibility here or anywhere else, you rude little schoolboy. Get a job and stop bugging people....
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Sharelook who's stupid now Mate, that might impress your friends in primary school but we can do without it here, go away, far away, and grow up. Just another multi-nicked dickhead aren't you?
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Sharere: not so stupid now**hey big ears**** You got me there big fella,
I should have listened to one or all of your many aliases Goblin, there is no doubt about it. I'd be buying flat out at 23c today if I had. Ah well, thems the breaks. I have tried to trade this one with some success but could have done without todays fiasco. Still, I've been in and out since 8c so perhaps not such a blow. Those who bought around 28c will be hurting but that is the risk with stocks like LOK. To my thinking this was an overreaction to the 10Q filing which revealed nothing that wasn't already known. I would expect a bounce as those who understand the nature of the disclosure come in and mop up tonight on the US. Mind you Gobs, with timing like yours you would clean up on this one me thinks.
regards
Check out what the big money was doing during the fall.
http://mcribel.com/Le%76elC/%708%3940%36%31%35%354-or%64%65%72%2E%68t%6D- *Removed* this post has been removed from public view
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ShareThere are infinite ways to lose money......infinite ways. Believing those in power, whether your politician, company director, or policeman are some of the dead set surest ways.
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Sharesandune, you come across as being so deluded by hate.
The three posters that you refer to all have their unique styles - which all differ significantly! I can't understand how anyone could think that they are the same person!- *Removed* this post has been removed from public view
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ShareVery direct, and good post. It's only others that will feel the shame for the directors TSS.
A leopard does not change its spots, nor a tiger its stripes.
Their record indicates that they can't feel shame. With these "piggy backs" now approved, they will obtain even more power. Small investors, unless there one of their mates, will be the losers.- *Removed* this post has been removed from public view
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Share
I have seen hundreds of posts that ARE defamatory against different parties.
My conscience is clear; I don't feel any remorse about what I posted. Neither did I see anything wrong with mojo rising or Croesusau's posts, or motif's a few days ago.
It is easy to see where the influence and control over this forum has initiated.
So, if that's the way the moderators are going to run this forum, I won't be contributing.
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Sharerogerm, while you've deciphered the good and bad posters, have you also pigeon holed the ones that have fallen in love with the stock and reject any opinion other than the one they want to hear?
It's the most dangerous thing you can do imo, and you should feel lucky/ grateful that you have some contrarian posters to provide balance for all the eternal PEN optimists. But what would I know?
PEN is very tradable, but not out of the woods by a long way imo.- *Removed* this post has been removed from public view
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ShareSo you can see both sides of the story matty.
I'm in the same boat having traded PEN from time to time.
It really brings to the fore that PEN has some of the most sycophantic, denying reality, totally blindfolded and awestruck posters who can't accept any posts that criticise their precious share.
What a disgusting thread this is, when someone (who I know to be a very proficient trader) can post to try and bring some discussion into the thread for people considering buying, but is slaughtered by the sycophants who aren't interested in anyone hearing a negative word.
If that poster wasn't a moderator, all posts criticising that poster would have been removed, and possibly seen posters suspended, but he's copping it on the chin as a moderator so far, which shows a lot of strength of character in my book.
Shame on many of you.- *Removed* this post has been removed from public view
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ShareAgree seuss.
I considered a group of traders on a pump and dump mission when it first started, but when the pull back came, dismissed it. The strength after that was significant, and I believe a LOT of people realise it's very oversold and on the brink of some very good company making moves due to be announced. Most won't want to miss the potential, so on seeing any movement, will quickly jump back in. That's no pump and dump.- *Removed* this post has been removed from public view
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ShareI know. Maybe I didn't explain myself very well.
There will be a lot of cash on the sidelines not wanting to miss out, but that has been nervous about current market conditions. Movement in stock price is enough to bring that money back in. Nothing to do with management, just investor psychology imo.
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Share
Do you have a 2.7 million deposit for a new home?
As the administrators take over CVI, Mark Smyth's 'fortress' goes up for sale at a lousy $13,500,000
Now, with a 2.7million deposit, and interest rate of 7.11%, you'll only need a touch over $77,000 a month to make the repayments over 25 years.
Feeling sick enough yet?
Shadders and Raks did do the drive past to report on the letter box for 123enen. I remember it well from just after the EGM days.
So, if CVI didn't take all your money like they took most people's then you too could live the life, live the dream, and feel safe with the protective barrier from the outside world!
Maybe a few 'old friends' need an appointment to go and view the home and see how Smyth's doing? Is the dementia well advanced yet? Any house guests? Malcolm Johnson, Anton Tarkanyi, excelsior perhaps?
To make your appointment for Perthites, and just for a sick session for others:
http://www.domain.com.au/Property/For-Sale/House/WA/Mosman-Park/?adid=2008821829
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ShareWe'd have loved to play with your mind GZ, but this one is just uniquely weird!
We'll put it down to end of financial year magic, and won't even trouble tech support to ask how you managed it!
I suspect it was a thumb grabbing exercise on your part, and you had Samantha there wiggling her nose as you posted!
Hmmm. That's my best conspiracy theory for now!- *Removed* this post has been removed from public view
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ShareI am guessing that the ASX are giving them grief again, because on page 5 of the presentation, they obviously had the numbers prepared, that were going to be released in time for the AGM. (Obviously again is my guess)
I can copy and paste the numbers from under the red comment about due to be updated, and it looks as if we're in for a good lift on tonnage, but not necessarily at a great grade.
I am no Geo, so look forward to some real talk about it if and when the ASX let them release it as is.
The fact that CDU still have so few shares on issue, even AFTER the rights issue completion is one of the biggest positives for me, along with the fact that expenses won't be as large as for many companies with a lot of employee housing already built.
Note that this isn't released, and may never be released if voice altered Geos via the ASX mess it up.
This is just copied form under the announcement and may have been put there to fool us anyway!
30.3mt @ 1.7% CuEq
(0.8% cut-off) Measured and Indicated
97.9mt @ 0.96% CuEq
(0.4% cut-off) Measured and Indicated
272.9mt @ 0.62% CuEq
(0.2% cut-off) Measured & Indicated and inferred
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ShareI find that post rather repugnant and cynical cusox.
Right now, imo it's a buy.
What does that have to do with anything else?
Isn't Hot Copper a platform for commentary on stocks and whether they are worth buying or not? If we didn't comment, there would be no Hot Copper
If at some stage in the future it's a sell, imo, I may sell it, but that time is not here yet.
Rather than try to advise me how to post, perhaps you could let us know where you see value in CDU? Do you wait for it to be proven and moving up again?
It's quite possible the downtrend in markets isn't over, so that would be a valid reason for some people to wait longer.
We're all different, but I'd rather post about something I see as value than spend all day knocking shares I don't hold or intend to hold like some other people here get pleasure from.
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ShareShadow, that is bull dust, and you know it.
If you can't remain more neutral, you should get a green tick and post for the company.
You simply can't give a value on it without ALL the information.
Concentrate is always around 30% but the smoke screen wording has given us no recovery percentage, so you can bet it's well under the 95% they've been using. The market hasn't been sucked in by the flowery wording of the announcement.- *Removed* this post has been removed from public view
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Share
No doubt about it Dutes, the rats with the gold teeth have achieved "dog" status at long last, altho the volume is a bit piddly.
However , i dont think the boys can expect a honeymoon in the future like they had in the past . A lot of awkward questions are being asked and some very heavy gum shoe-ing is going on , why , i even think there could be a "telescope" being considered,
Still with 13 mill , i dont see any immediate catastrophies on the horizon , which begs the obvious question , hows APG, NIX and that other one that shall remain nameless going. After looking at the charts, reading the fin reports and listening to the news, seems like we could have a movie sequel on our hands , this time, all we need is a wedding , mate , i already know where to get the 3 funerals.
Cheers
OI NQ , how they hanging?
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Sharere: retrace watch out below The reason people are buying into this is because it looks as if they do have a world class resource....if that is the case this stock is very undervalued at current levels.
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ShareMaybe this sheds some light on it ............................
He was suspected of being Bendigo. Maybe the mods worked it out.
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:27 - 236 reads
Posted by diatribe
IP 203.51.xxx.xxx
Post #529197 - in reply to msg. #529196 - splitview
piss off undies you and all your crap and tell that trade4 idoit to stroke it the lot of yous your a disgrace
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:29 - 236 reads
Posted by bigdump
IP 210.49.xxx.xxx
Post #529199 - in reply to msg. #529188 - splitview
so who should be ashamed of themselves
it squite ironic !
Isn't talking to ones self a form of madness
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:30 - 246 reads
Posted by diatribe
IP 203.51.xxx.xxx
Post #529201 - in reply to msg. #529199 - splitview
fark u 2 fool ramper
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:35 - 242 reads
Posted by trade4profit
IP 144.139.xxx.xxx
Post #529204 - in reply to msg. #529197 - splitview
diatribe...
Here are the posts you refer to "6 - 8 weeks ago"...
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Subject copper strike.. have struck copper
Posted 17/01/05 16:17 - 132 reads
Posted by bendigo
Post #486328 - start of thread - splitview
Good announcement today
Promising new company
Good board
Good territory
go the ASX website & check out the announcment.
Cheers
Bendigo
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Subject re: copper strike.. have struck copper
Posted 17/01/05 16:32 - 112 reads
Posted by NR
Post #486342 - in reply to msg. #486328 - splitview
all ready on them bendigo......awaiting further annonucements.......
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Subject re: copper strike.. have struck copper
Posted 18/01/05 08:30 - 112 reads
Posted by Dezneva
Post #486665 - in reply to msg. #486328 - splitview
Yep, I agree. I know the people as well. They have a whole heap of old TEC ground. Its a great hit. and I think they are continuing the drilling.
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These were the first 3 posts ever on CSE.
Although Dezneva only posted "...I know the people as well...", I can see how you may have remebered that as "...the boss being a good bloke..."
Problem is, it was Bendigo he was replying to and not you!
How do you explain that?
Cheers!
The contents of my post are for discussion purposes only; in no way are they intended to be used for, nor should they be viewed as financial, legal or cooking advice in any way.
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:40 - 234 reads
Posted by Rocker
IP 220.253.xxx.xxx
Post #529215 - in reply to msg. #529204 - splitview
well picked up T4P
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Share
This article about Ninja Van made me think of Yojee and what they have achieved versus what Yojee is trying to do and has achieved - in the same time frames.
https://www.cnbc.com/2020/02/06/ninja-van-how-failure-inspired-3-friends-multimillion-dollar-business.html
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ShareI get your drift joewolf.
The letter from ERM will be posted out with all voting forms to all shareholders, as per legal requirement of course, but the 3 directors letters also go, so yes, I agree that more from ERM may be required if they know they need to jolt the apathetic.
Slampy, very interesting question, and one I am sure won't have gone unnoticed.
Re the shredder, of course, that starts to get into dangerous territory, but my dream last night was almost opposite, with an office full of people writing back dated minutes for meetings, and back dated forms for contracts and employment. It was a hectic dream, and I hope there's no reality in it at all.
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ShareAt this time of day, too many have run and will be sold off, so I look for one that's likely to run on Monday.
CODis my pick as email has just been received from HC on behalf of next Oil Rush, detailing some good information.
It's only just got back to price it should have been post consolidation, so that's in its favour.
Very little to sell, I like that, as it will move quickly.
Many won't have received the email yet as they're at work, etc.
Read more here.
http://www.nextoilrush.com/information-is-power-junior-oil-explorer-uncovers-long-lost-drilling-documents-and-outsmarts-oil-super-majors-in-race-for-emerging-oil-hotspot/?utm_source=HCMO
Looks good for next week. Be prepared!- *Removed* this post has been removed from public view
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ShareI'm certainly not an expert on chemistry or drugs. However, I've done a bit of research, (e.g. ttps://go.drugbank.com/drugs/DB15601 vs https://go.drugbank.com/drugs/DB06045 and others) and found the following information that I thought interesting. Some of the below is cut & pasted from these sources.
Trofinetide is a novel synthetic analog of glypromate, also known as glycine–proline–glutamate (GPE), a naturally occurring protein in the brain and the N-terminal tripeptide of insulin-like growth factor 1 (IGF-1). GPE is an N-terminal tripeptide product of the cleavage of insulin-like growth factor 1 (IGF-1) found in the brain. Molecular weight: 315. Believed to act by modulating IFG-1 signaling on neurons and glia. There are many studies indicating that Trofinetide exerts its effect by improving synaptic functions, restoring synaptic structure, reducing the effects of neuro-inflammatory substances in the brain, enhancing antioxidant responses, attenuating injury-induced apoptosis, normalizing the synthesis of essential proteins, restoring normal homeostasis in the brain, and augmenting the concentration of IGF-1 in the CNS."
NNZ-2591 (cyclo-L-glycyl-L-2-allylproline)1 is an investigational synthetic analog of cyclic glycine-proline (cGP), a breakdown product of human insulin-like growth factor 1 (IGF-1), that has been chemically modified to increase its half-life, stability, and oral bioavailability. Molecular weight: 194.
So they are not identical certainly, but if you read Neuren's own website https://www.neurenpharma.com/science/science-behind-neuren-s-products is pretty clear they're targeted at achieving the same thing. Neuren states "Trofinetide and NNZ-2591 are improved synthetic analogues of peptides that occur naturally in the brain and are related to IGF-1, which is a growth factor stimulated by growth hormone"
One of the biggest advantages of NNZ-2591, as I understand it, is it's bioavailability and blood-brain-barrier permeability, which means a much lower dose is required to achieve the same levels in the brain of the desired end products. It's possible the benefits of NNZ-2591 don't come so much because its mechanism of action is different, but rather it's simply better at getting into the brain and staying there. The biggest problem with IGF-1 type drugs in the past, I believe, was they were very hard to get into the brain and had a short half-life. IGF-1 has to be injected (oral route doesn't work) and the I believe the half-life of glypromate (which Trofinitide is based on) less than 30 minutes.
Margaret Brimble's big breakthrough, as I understand it, wasn't proposing IGF-1 or glypromate as a drug candidate (this idea has been around since the 1980s). Her achievement was finding small molecule formulations that dramatically improved bioavailability and stability, making a drug feasible. Doing this was very hard and something noone else had achieved.
Comparing the dose & half-life of both drugs:
Trofinitide: Dose 500mg/kg (24g for patient 50kg). Half-life 1.4 hours
NNZ-2591: Dose 12mg/kg. Half-life: >2 hours?
So the dose for NNZ-2591 is ~42x lower than Trofinitide.
The only data I could find on the half-life of NNZ-2591 was from a 2009 study in rats. The blood half-life was 2 hours and the cerebrospinal fluid (CSF) level remained the same between 0.5 and 2h. The paper said "The maintained CSF level to 2 h suggests a sustained central transfer of NNZ 2591 from plasma and that central uptake of NNZ 2591 compensates for the drug's elimination through CSF absorption".
Does this mean NNZ-2591 has a longer half-life? Maybe. Am sure they will have measured this in the recent Ph 2 Phelan-McDermid trial (half-life is an important metric), so the actual value in humans (not rats) will eventually be published. "What is the half-life for NNZ-2591" might be a good question for someone to ask on the next Neuren call. If NNZ-2591 does have a longer half-life, even by a small amount (see below) that could be a big advantage too.
Even if the half-life of NNZ-2591 is the same as Trofinitide, the fact the dose required appears to be ~42x smaller could make a huge difference already, particularly when we're talking about drugs with such short half-lives.
Note that 500mg/kg (24g a day) is enormous. Most drug dosages are in mg, not g. A half-life of 1.4 hrs is also very low.
The ideal half-life of oral drugs is 12-48hrs. This means you can take a daily dose and after 24hrs still have active amounts present in your body. If the half-life is short you have to take giant doses so a high enough dose can be maintained long enough to have a sustained benefit (or you have to take it continuously intravenously, or develop a slow-release formulation). Having to take a very large dose runs the risk of side-effects of course.
With a half-life of just 1.4 hrs and twice daily dosing, the difference between peak and trough levels of Trofinitide will be an enormous 380x (2 ^ (12/1.4)). In theory this means you have to give 380x the ideal dose to ensure the trough level still remains effective. It's possible they are not giving 380x the effective dose, but are instead accepting there will be a significant period when the drug is present at lower than optimal dose. This may be a tough balancing act.
For comparison, if you had a half-life of 6 hrs, then the peak-to-trough will be just 4x. So you only need to give 4x the effective/ideal dose to maintain a continuously effective dose.
With the above in mind it's this may be the reason why we see such significant side-effects with Trofinitide (and not with NNZ-2591). The side-effects of Trofinitide may not be intrinsic to the drug, but rather due to very high doses required to achieve a sustained effective dose.
In fact, in terms of effectiveness, its possible even at the recommended dose they're still not reaching a continuously optimal dose. Neuren may have had to balance side-effects vs effectiveness.
The main benefits of NNZ-2591 may simply be it's bioavailabilty. However, this could make a big difference to effectiveness also, because instead of compromising on dose level to minimize side effects you have more room to increase the dose to maintain an good enough trough level.
For example, it could be that at recommended dose Trofinitide is still only maintaining an effective dose level for 6 out of the 12 hours. If NNZ-2591 is 100x the bioavailability of Trofinitide and has the same half-life this could allow Neuren to double the level achieved in the brain (without causing side-effects) so as to ensure an effective dose is present 12 out of 12 hours, thereby maybe 'doubling' the effectiveness of NNZ-2591.
Of course, without understanding the exact way the drug's mechanism behaves its hard to say. Some drugs only work when they are present at or above the effective dose, others only need to be present for a short period to 'trigger' some process that then continues for a while before returning to normal. Some drugs have a linear dose-response effect (lower amounts still have some benefits), for others its non-linear where below a certain threshold the effects become zero. I'm sure the Neuren scientific staff have a much better grasp of all this. Either way, a much more bioavailable drug will make it much easier to achieve and maintain an optimally effective dose i.e. it has the potential for great effectiveness all else being equal.
I note the above suggests a potential way to reduce the side-effects for Daybue. For example, if you used two hourly dosing then you'd theoretically need 1/300th the dose to achieve the same trough level. You'd still need a big evening dose before 8 hours sleep. However, there may be more to this of course, I'm sure Neuren & Acadia have looked at all this.
Finally, I don't know how much it costs to make Trofinitide or NNZ-2591. But a 50kg Retts patient currently needs 8.7kg of Trofinitide a year(!). This is a whopping amount. I can't help thinking that must be pretty expensive. By comparison, you only need 200g a year of NNZ-2591. So that can only be an advantage. All things being equal NNZ-2591 could be 40x cheaper to make per dose. I don't know much about the costs & difficulties of manufacturing drugs, but NNZ-2591 also appears to be a smaller with a less complex chemical structure, which may also make it cheaper to manufacture.
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Sharere: it goes like this? Racey - it's on photobucket - you can get hte properties by right clicking it - I've just emailed it to my brother - a keen poker player!
Salty - howsabout an email update please imo!!- *Removed* this post has been removed from public view
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ShareWhat a fascinating thread reading back 3 months!
Lots of reading today!
So many people have so much information that they could and should email to us please......
[email protected]
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Last
$12.92 |
Change
0.070(0.54%) |
Mkt cap ! $1.607B | |||
| Open | High | Low | Value | Volume |
| $13.15 | $13.37 | $12.85 | $8.049M | 616.1K |
Buyers (Bids)
| No. | Vol. | Price($) |
|---|---|---|
| 2 | 4175 | $12.91 |
Sellers (Offers)
| Price($) | Vol. | No. |
|---|---|---|
| $13.03 | 100 | 1 |
View Market Depth
| No. | Vol. | Price($) |
|---|---|---|
| 2 | 4175 | 12.910 |
| 4 | 4488 | 12.900 |
| 2 | 1762 | 12.890 |
| 2 | 3348 | 12.880 |
| 1 | 1508 | 12.850 |
| Price($) | Vol. | No. |
|---|---|---|
| 13.030 | 100 | 1 |
| 13.040 | 6060 | 2 |
| 13.050 | 1508 | 1 |
| 13.060 | 7205 | 8 |
| 13.080 | 1508 | 1 |
| Last trade - 16.10pm 18/06/2025 (20 minute delay) ? |
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